For endometrial cancer, search as for virtually every form of cancer, advances in genomics are transforming the understanding and treatment of this disease, which arises in the lining of the uterus or womb.
As part of the Profile research project at Dana-Farber, Brigham and Women’s Hospital, and Boston Children’s Hospital, investigators have scanned hundreds of endometrial tumor samples for genetic abnormalities associated with cancer. As more and more samples are analyzed, scientists are exploring whether endometrial cancer is a fairly uniform disease, or, more likely, whether it comprises several molecular subtypes, each with its own set of genetic flaws.
These efforts have already yielded some valuable insights. Researchers recently found, for example, that the genes ARID1A and POLE are often mutated in endometrial cancers, says Panos Konstantinopoulos, MD, PhD, of the Gynecologic Oncology Program at the Susan F. Smith Center for Women’s Cancers at Dana-Farber.
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