13
Oct

Gene that drives aggressive prostate cancer identified

An overactive gene appears to cause some prostate cancers to transform from a typical tumor type to a much more aggressive form of the disease, link according to new research at Weill Cornell Medicine.

Prostate cancer is the second most common cancer in men, behind skin cancer. Approximately 15 percent of men in the United States will be diagnosed with the disease at some point in their lives. Most prostate cancers are a type called adenocarcinoma, which develops in the gland cells in the prostate. These cancers are regulated by male hormones called androgens. Advanced adenocarcinoma of the prostate is treated with drugs that cut off the supply of androgens. This is typically effective in slowing the growth of the cancer, but these tumors are increasingly becoming resistant to androgen-blocking treatment and progressing to a more aggressive disease called neuroendocrine prostate cancer.

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