LLNL scientists develop a new method to measure radiation dose in cancer patients

Lawrence Livermore National Laboratory (LLNL) scientists and collaborators have developed a new technique to measure radiation dose levels using gene expression analysis of whole blood from cancer patients receiving targeted radiation therapy.

There are unique challenges to estimate the internal dose after radiotherapy is administered. The current practice of calculating internal radiation dose is done by either bioassay (such as urine or fecal samples) or by using biokinetic models to estimate radioactivity as provided by the Committee on Medical Internal Radiation Dose (MIRD).

Radiotherapy is a therapy using ionizing radiation, pharmacy generally as part of cancer treatment to control or kill malignant cells. Radiation therapy may be beneficial in a number of cancer types if these cancers are localized to one area of the body. It also may be used to prevent tumor recurrence after surgery upon removal of a primary malignant tumor.

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