Antibiotics May Compromise Immunotherapy Efficacy in Kidney Cancer

Patients with metastatic kidney cancer may see a decreased efficacy of their immunotherapy regimen if they recently took antibiotics.

Immunotherapy efficacy may be compromised if the patient takes antibiotics up to a month before treatment, according to the results of a retrospective analysis presented during a presscast of the 2017 Genitourinary Cancers Symposium, which raised concern about the relationship between gut microbacteria and antibiotics and their effect on immune checkpoint blockade agents.

In patients with metastatic renal cell carcinoma (mRCC), patients who had received broad-spectrum antibiotics had a shorter median progression-free survival (PFS) rate when treated with checkpoint inhibitor immunotherapy than those who had not received antibiotics of 2.3 versus 8.1 months, respectively.

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