Sequencing prostate tumors from African-American men reveals a novel tumor suppressor gene
African-American men develop prostate cancer more often than other men, and it tends to be more deadly for this population. Some of the differences seem to be due to socioeconomic factors, but scientists wondered whether the disparities are also rooted in the tumor genome.
To explore whether racial disparities in prostate cancer incidence and prognosis stem from molecular and genetic differences, a team of researchers at the Broad Institute of MIT and Harvard including Broad institute member Levi Garraway and postdoctoral researcher Franklin Huang gathered tumor samples from 102 African-American men with prostate cancer and analyzed their exomes. The work appears in Cancer Discovery.
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